Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Ca(i)(2+) signaling in human ADPKD cyst epithelial cells

Flow-induced cytosolic Ca(2+) Ca(i)(2+) signaling in renal tubular epithelial cells is mediated in part through P2 receptor (P2R) activation by locally released ATP. The ability of P2R to regulate salt and water reabsorption has suggested a possible contribution of ATP release and paracrine P2R acti...

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Main Authors: Xu, Chang, Shmukler, Boris E., Nishimura, Katherine, Kaczmarek, Elzbieta, Rossetti, Sandro, Harris, Peter C., Wandinger-Ness, Angela, Bacallao, Robert L., Alper, Seth L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2009
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692447/
https://ncbi.nlm.nih.gov/pubmed/19244404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90542.2008
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