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Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Ca(i)(2+) signaling in human ADPKD cyst epithelial cells

Flow-induced cytosolic Ca(2+) Ca(i)(2+) signaling in renal tubular epithelial cells is mediated in part through P2 receptor (P2R) activation by locally released ATP. The ability of P2R to regulate salt and water reabsorption has suggested a possible contribution of ATP release and paracrine P2R acti...

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書誌詳細
主要な著者: Xu, Chang, Shmukler, Boris E., Nishimura, Katherine, Kaczmarek, Elzbieta, Rossetti, Sandro, Harris, Peter C., Wandinger-Ness, Angela, Bacallao, Robert L., Alper, Seth L.
フォーマット: Artigo
言語:Inglês
出版事項: American Physiological Society 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692447/
https://ncbi.nlm.nih.gov/pubmed/19244404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.90542.2008
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