A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

Primary cilia regulate epithelial differentiation and organ function. Failure of mutant polycystins to localize to cilia abolishes flow-stimulated calcium signaling and causes autosomal dominant polycystic kidney disease. We identify a conserved amino acid sequence, KVHPSST, in the C-terminus of pol...

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Autores principales: Ward, Heather H., Brown-Glaberman, Ursa, Wang, Jing, Morita, Yoshiko, Alper, Seth L., Bedrick, Edward J., Gattone, Vincent H., Deretic, Dusanka, Wandinger-Ness, Angela
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2011
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172256/
https://ncbi.nlm.nih.gov/pubmed/21775626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-01-0082
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