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Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA(+) Lon protease
Human mitochondrial transcription factor A (TFAM) is a high-mobility group (HMG) protein at the nexus of mitochondrial DNA (mtDNA) replication, transcription and inheritance. Little is known about the mechanisms underlying its post-translational regulation. Here, we demonstrate that TFAM is phosphor...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586414/ https://ncbi.nlm.nih.gov/pubmed/23201127 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.023 |
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