Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA(+) Lon protease

Human mitochondrial transcription factor A (TFAM) is a high-mobility group (HMG) protein at the nexus of mitochondrial DNA (mtDNA) replication, transcription and inheritance. Little is known about the mechanisms underlying its post-translational regulation. Here, we demonstrate that TFAM is phosphor...

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Main Authors: Lu, Bin, Lee, Jae, Nie, Xiaobo, Li, Min, Morozov, Yaroslav I., Venkatesh, Sundararajan, Bogenhagen, Daniel F., Temiakov, Dmitry, Suzuki, Carolyn K.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586414/
https://ncbi.nlm.nih.gov/pubmed/23201127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.10.023
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