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The CXXC motifs in the metal binding domains are required for ATP7B to mediate resistance to cisplatin()
The copper (Cu) exporter ATP7B mediates resistance to cisplatin (cDDP) but details of the mechanism are unknown. We explored the role of the CXXC motifs in the metal binding domains (MBDs) of ATP7B by investigating binding of cDDP to the sixth metal binding domain (MBD6) or a variant in which the CX...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586266/ https://ncbi.nlm.nih.gov/pubmed/22459168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2012.02.016 |
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