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Effects of the loss of Atox1 on the cellular pharmacology of cisplatin
Previous work has demonstrated that the copper (Cu) transporters Ctr1, Atp7a and Atp7b regulate the cellular pharmacology of cisplatin (CDDP) by mediating its uptake and efflux. It was also shown that, in the process of uptake by Ctr1, CDDP triggers the rapid proteasomal degradation of its own trans...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2919289/ https://ncbi.nlm.nih.gov/pubmed/19124158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2008.11.012 |
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