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Copper Transporters and the Cellular Pharmacology of the Platinum-Containing Cancer Drugs

Multiple lines of evidence indicate that the platinum-containing cancer drugs enter cells, are distributed to various subcellular compartments, and are exported from cells via transporters that evolved to manage copper homeostasis. The cytotoxicity of the platinum drugs is directly related to how mu...

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Detalhes bibliográficos
Main Authors: Howell, Stephen B., Safaei, Roohangiz, Larson, Christopher A., Sailor, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Pharmacology and Experimental Therapeutics 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202487/
https://ncbi.nlm.nih.gov/pubmed/20159940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.063172
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