Inhibition of Norovirus 3CL Protease by Bisulfite Adducts of Transition State Inhibitors

Noroviruses are the most common cause of acute viral gastroenteritis, accounting for >21 million cases annually in the U.S. alone. Norovirus infections constitute an important health problem for which there are no specific antiviral therapeutics or vaccines. In this study, a series of bisulfite a...

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Hauptverfasser: Mandadapu, Sivakoteswara Rao, Gunnam, Mallikarjuna Reddy, Tiew, Kok-Chuan, Uy, Roxanne Adeline Z., Prior, Allan M., Alliston, Kevin R., Hua, Duy H., Kim, Yunjeong, Chang, Kyeong-Ok, Groutas, William C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586229/
https://ncbi.nlm.nih.gov/pubmed/23218713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2012.11.026
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