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Pharmacokinetic Drug Interactions with Vandetanib during Coadministration with Rifampicin or Itraconazole
Objective: The aim of this study was to investigate the effects of a potent CYP3A4 inducer, rifampicin (Study A), and a potent CYP3A4 inhibitor, itraconazole (Study B), on the pharmacokinetics of a single 300mg dose of vandetanib in healthy subjects. Study Design and Setting: Two phase I, randomized...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer International Publishing
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586143/ https://ncbi.nlm.nih.gov/pubmed/21410294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2165/11586980-000000000-00000 |
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