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Coadministration of voriconazole and phenytoin: pharmacokinetic interaction, safety, and toleration

AIMS: Voriconazole is a new triazole antifungal agent, and is metabolized by the cytochrome P450 isoenzymes CYP2C9, CYP2C19, and, to a lesser extent, by CYP3A4. Phenytoin is an inducer of CYP3A4 activity, and a substrate and inducer of CYP2C9 and CYP2C19. The present studies investigated the pharmac...

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Bibliografski detalji
Glavni autori: Purkins, Lynn, Wood, Nolan, Ghahramani, Parviz, Love, Edward R, Eve, Malcolm D, Fielding, Anitra
Format: Artigo
Jezik:Inglês
Izdano: Blackwell Science Inc 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884312/
https://ncbi.nlm.nih.gov/pubmed/14616412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1046/j.1365-2125.2003.01997.x
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