Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

BACKGROUND: Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players...

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Bibliographische Detailangaben
Hauptverfasser: Larsson-Callerfelt, Anna-Karin, Hallgren, Oskar, Andersson-Sjöland, Annika, Thiman, Lena, Björklund, Johan, Kron, Josefine, Nihlberg, Kristian, Bjermer, Leif, Löfdahl, Claes-Göran, Westergren-Thorsson, Gunilla
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585859/
https://ncbi.nlm.nih.gov/pubmed/23406566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-21
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