Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

BACKGROUND: Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players...

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Autori principali: Larsson-Callerfelt, Anna-Karin, Hallgren, Oskar, Andersson-Sjöland, Annika, Thiman, Lena, Björklund, Johan, Kron, Josefine, Nihlberg, Kristian, Bjermer, Leif, Löfdahl, Claes-Göran, Westergren-Thorsson, Gunilla
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2013
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585859/
https://ncbi.nlm.nih.gov/pubmed/23406566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-21
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