Defective alterations in the collagen network to prostacyclin in COPD lung fibroblasts

BACKGROUND: Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players...

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Autors principals: Larsson-Callerfelt, Anna-Karin, Hallgren, Oskar, Andersson-Sjöland, Annika, Thiman, Lena, Björklund, Johan, Kron, Josefine, Nihlberg, Kristian, Bjermer, Leif, Löfdahl, Claes-Göran, Westergren-Thorsson, Gunilla
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2013
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585859/
https://ncbi.nlm.nih.gov/pubmed/23406566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-14-21
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