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MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination

The PALB2 protein is associated with breast cancer susceptibility and Fanconi anemia. Notably, PALB2 is also required for DNA repair by homologous recombination (HR). However, the mechanisms that regulate PALB2, and the functional significance of its interaction with the BRCA1 breast cancer suscepti...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Fan, Bick, Gregory, Park, Jung-Young, Andreassen, Paul R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585519/
https://ncbi.nlm.nih.gov/pubmed/23038782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.111872
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