On Terminal Alkynes That Can React with Active-Site Cysteine Nucleophiles in Proteases

[Image: see text] Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive. By replacing the C-terminal carboxylate of ubiquitin (Ub) with an alkyne functionality, a selective reaction with the...

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Detalhes bibliográficos
Main Authors: Ekkebus, Reggy, van Kasteren, Sander I., Kulathu, Yogesh, Scholten, Arjen, Berlin, Ilana, Geurink, Paul P., de Jong, Annemieke, Goerdayal, Soenita, Neefjes, Jacques, Heck, Albert J. R., Komander, David, Ovaa, Huib
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585465/
https://ncbi.nlm.nih.gov/pubmed/23387960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja309802n
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