Poxvirus Targeting of E3 Ligase β-TrCP by Molecular Mimicry: A Mechanism to Inhibit NF-κB Activation and Promote Immune Evasion and Virulence

The transcription factor NF-κB is essential for immune responses against pathogens and its activation requires the phosphorylation, ubiquitination and proteasomal degradation of IκBα. Here we describe an inhibitor of NF-κB from vaccinia virus that has a closely related counterpart in variola virus,...

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Bibliografiske detaljer
Main Authors: Mansur, Daniel S., Maluquer de Motes, Carlos, Unterholzner, Leonie, Sumner, Rebecca P., Ferguson, Brian J., Ren, Hongwei, Strnadova, Pavla, Bowie, Andrew G., Smith, Geoffrey L.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3585151/
https://ncbi.nlm.nih.gov/pubmed/23468625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003183
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