Intraductal administration of a polymeric nanoparticle formulation of curcumin (NanoCurc) significantly attenuates incidence of mammary tumors in a rodent chemical carcinogenesis model: Implications for breast cancer chemoprevention in at-risk populations

Multiple lines of evidence support a role for curcumin in cancer chemoprevention. Nonetheless, despite its reported efficacy and safety profile, clinical translation of curcumin has been hampered by low oral bioavailability, requiring infeasible ‘mega’ doses for achieving detectable tissue levels. W...

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Main Authors: Chun, Yong Soon, Bisht, Savita, Chenna, Venugopal, Pramanik, Dipankar, Yoshida, Takahiro, Hong, Seung-Mo, de Wilde, Roeland F., Zhang, Zhe, Huso, David L., Zhao, Ming, Rudek, Michelle A., Stearns, Vered, Maitra, Anirban, Sukumar, Saraswati
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
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Original Manuscript
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584967/
https://ncbi.nlm.nih.gov/pubmed/22831956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs248
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