Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification

Human genetic disorders sharing the common feature of subcutaneous heterotopic ossification (HO) are caused by heterozygous inactivating mutations in GNAS, a gene encoding multiple transcripts including two stimulatory G-proteins, the α-subunit of the stimulatory G-protein (G(s)α) of adenylyl cyclas...

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Autori principali: Pignolo, Robert J., Xu, Meiqi, Russell, Elizabeth, Richardson, Alec, Kaplan, Josef, Billings, Paul C., Kaplan, Frederick S., Shore, Eileen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584579/
https://ncbi.nlm.nih.gov/pubmed/21812029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.481
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