Heterozygous inactivation of Gnas in adipose-derived mesenchymal progenitor cells enhances osteoblast differentiation and promotes heterotopic ossification

Human genetic disorders sharing the common feature of subcutaneous heterotopic ossification (HO) are caused by heterozygous inactivating mutations in GNAS, a gene encoding multiple transcripts including two stimulatory G-proteins, the α-subunit of the stimulatory G-protein (G(s)α) of adenylyl cyclas...

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Hauptverfasser: Pignolo, Robert J., Xu, Meiqi, Russell, Elizabeth, Richardson, Alec, Kaplan, Josef, Billings, Paul C., Kaplan, Frederick S., Shore, Eileen M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584579/
https://ncbi.nlm.nih.gov/pubmed/21812029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.481
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