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Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification
Bone formation is exquisitely controlled in space and time. Heterotopic ossification (HO), the pathologic formation of extra-skeletal bone, occurs as a common complication of trauma or in genetic disorders and can be disabling and lethal. However, the underlying molecular mechanisms are largely unkn...
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| Main Authors: | , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2013
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3917515/ https://ncbi.nlm.nih.gov/pubmed/24076664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3314 |
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