Mutagenesis of a Specificity-Determining Residue in Tyrosine Hydroxylase Establishes that the Enzyme is a Robust Phenylalanine Hydroxylase but a Fragile Tyrosine Hydroxylase()

The aromatic amino acid hydroxylases tyrosine hydroxylase (TyrH) and phenylalanine hydroxylase (PheH) have essentially identical active sites, but PheH is nearly incapable of hydroxylating tyrosine, while TyrH can readily hydroxylate both tyrosine and phenylalanine. Previous studies have indicated t...

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Detalhes bibliográficos
Main Authors: Daubner, S. Colette, Avila, Audrey, Bailey, Johnathan O., Barrera, Dimitrios, Bermudez, Jaclyn Y., Giles, David H., Khan, Crystal A., Shaheen, Noel, Thompson, Janie Womac, Vasquez, Jessica, Oxley, Susan P., Fitzpatrick, Paul F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584195/
https://ncbi.nlm.nih.gov/pubmed/23368961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400031n
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