An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects

Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (...

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Main Authors: Ma, Lijun, Murea, Mariana, Snipes, James A., Marinelarena, Alejandra, Krüger, Jacqueline, Hicks, Pamela J., Langberg, Kurt A., Bostrom, Meredith A., Cooke, Jessica N., Suzuki, Daisuke, Babazono, Tetsuya, Uzu, Takashi, Tang, Sydney C. W., Mondal, Ashis K., Sharma, Neeraj K., Kobes, Sayuko, Antinozzi, Peter A., Davis, Matthew, Das, Swapan K., Rasouli, Neda, Kern, Philip A., Shores, Nathan J., Rudel, Lawrence L., Blüher, Matthias, Stumvoll, Michael, Bowden, Donald W., Maeda, Shiro, Parks, John S., Kovacs, Peter, Hanson, Robert L., Baier, Leslie J., Elbein, Steven C., Freedman, Barry I.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584087/
https://ncbi.nlm.nih.gov/pubmed/23460794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056193
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