An ACACB Variant Implicated in Diabetic Nephropathy Associates with Body Mass Index and Gene Expression in Obese Subjects

Acetyl coenzyme A carboxylase B gene (ACACB) single nucleotide polymorphism (SNP) rs2268388 is reproducibly associated with type 2 diabetes (T2DM)-associated nephropathy (DN). ACACB knock-out mice are also protected from obesity. This study assessed relationships between rs2268388, body mass index (...

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Главные авторы: Ma, Lijun, Murea, Mariana, Snipes, James A., Marinelarena, Alejandra, Krüger, Jacqueline, Hicks, Pamela J., Langberg, Kurt A., Bostrom, Meredith A., Cooke, Jessica N., Suzuki, Daisuke, Babazono, Tetsuya, Uzu, Takashi, Tang, Sydney C. W., Mondal, Ashis K., Sharma, Neeraj K., Kobes, Sayuko, Antinozzi, Peter A., Davis, Matthew, Das, Swapan K., Rasouli, Neda, Kern, Philip A., Shores, Nathan J., Rudel, Lawrence L., Blüher, Matthias, Stumvoll, Michael, Bowden, Donald W., Maeda, Shiro, Parks, John S., Kovacs, Peter, Hanson, Robert L., Baier, Leslie J., Elbein, Steven C., Freedman, Barry I.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584087/
https://ncbi.nlm.nih.gov/pubmed/23460794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056193
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