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Molecular Basis of Differential Sensitivity of Myeloma Cells to Clinically Relevant Bolus Treatment with Bortezomib

The proteasome inhibitor bortezomib (Velcade) is prescribed for the treatment of multiple myeloma. Clinically achievable concentrations of bortezomib cause less than 85% inhibition of the chymotrypsin-like activity of the proteasome, but little attention has been paid as to whether in vitro studies...

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Bibliografiske detaljer
Main Authors: Shabaneh, Tamer B., Downey, Sondra L., Goddard, Ayrton L., Screen, Michael, Lucas, Marcella M., Eastman, Alan, Kisselev, Alexei F.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3584083/
https://ncbi.nlm.nih.gov/pubmed/23460792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056132
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