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Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines

BACKGROUND: Geldanamycin (GA) can be considered a relatively new component with a promising mode of action against human malignancies. It specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone. METHODS: In this study, we have investigated the eff...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Karkoulis, Panagiotis K, Stravopodis, Dimitrios J, Konstantakou, Eumorphia G, Voutsinas, Gerassimos E
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583703/
https://ncbi.nlm.nih.gov/pubmed/23394616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-13-11
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