Wird geladen...

17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

BACKGROUND: 17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains the structural and functional integrity of various protein clients involved in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Karkoulis, Panagiotis K, Stravopodis, Dimitrios J, Margaritis, Lukas H, Voutsinas, Gerassimos E
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944179/
https://ncbi.nlm.nih.gov/pubmed/20828379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-481
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!