17-Allylamino-17-demethoxygeldanamycin induces downregulation of critical Hsp90 protein clients and results in cell cycle arrest and apoptosis of human urinary bladder cancer cells

BACKGROUND: 17-Allylamino-17-demethoxygeldanamycin (17-AAG), a benzoquinone ansamycin antibiotic, specifically targets heat shock protein 90 (Hsp90) and interferes with its function as a molecular chaperone that maintains the structural and functional integrity of various protein clients involved in...

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Main Authors: Karkoulis, Panagiotis K, Stravopodis, Dimitrios J, Margaritis, Lukas H, Voutsinas, Gerassimos E
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2010
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2944179/
https://ncbi.nlm.nih.gov/pubmed/20828379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-10-481
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