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Continuous inhibition of epidermal growth factor receptor phosphorylation by erlotinib enhances antitumor activity of chemotherapy in erlotinib-resistant tumor xenografts

Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, has been shown to have benefits for non-small cell lung cancer and pancreatic cancer patients; however, almost all patients develop progressive disease during the therapy. On the other hand, it has been reported that a tumor c...

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Bibliographic Details
Main Authors: IWAI, TOSHIKI, MORIYA, YOICHIRO, SHIRANE, MASATOSHI, FUJIMOTO-OUCHI, KAORI, MORI, KAZUSHIGE
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583539/
https://ncbi.nlm.nih.gov/pubmed/22209766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/or.2011.1614
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