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Divergent functions for eIF4E and S6 kinase by Sonic hedgehog mitogenic signaling in the developing cerebellum
Cerebellar development entails rapid peri-natal proliferation of cerebellar granule neuron precursors (CGNPs), proposed cells-of-origin for certain medulloblastomas. CGNPs require insulin-like growth factor (IGF) for survival and Sonic hedgehog (Shh)--implicated in medulloblastoma--for proliferation...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3583293/ https://ncbi.nlm.nih.gov/pubmed/21339731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.564 |
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