Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation

The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the developing cerebellum. SHH-MBs can be further subdivided based on molecular and clinical parameters, as well as location beca...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Tan, I-Li, Wojcinski, Alexandre, Rallapalli, Harikrishna, Lao, Zhimin, Sanghrajka, Reeti M., Stephen, Daniel, Volkova, Eugenia, Korshunov, Andrey, Remke, Marc, Taylor, Michael D., Turnbull, Daniel H., Joyner, Alexandra L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879676/
https://ncbi.nlm.nih.gov/pubmed/29531057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717815115
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