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Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation
The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the developing cerebellum. SHH-MBs can be further subdivided based on molecular and clinical parameters, as well as location beca...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5879676/ https://ncbi.nlm.nih.gov/pubmed/29531057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717815115 |
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