Lateral cerebellum is preferentially sensitive to high sonic hedgehog signaling and medulloblastoma formation

The main cell of origin of the Sonic hedgehog (SHH) subgroup of medulloblastoma (MB) is granule cell precursors (GCPs), a SHH-dependent transient amplifying population in the developing cerebellum. SHH-MBs can be further subdivided based on molecular and clinical parameters, as well as location beca...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Tan, I-Li, Wojcinski, Alexandre, Rallapalli, Harikrishna, Lao, Zhimin, Sanghrajka, Reeti M., Stephen, Daniel, Volkova, Eugenia, Korshunov, Andrey, Remke, Marc, Taylor, Michael D., Turnbull, Daniel H., Joyner, Alexandra L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2018
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879676/
https://ncbi.nlm.nih.gov/pubmed/29531057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1717815115
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