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Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

BACKGROUND: Alzheimer’s disease (AD) is the most frequently diagnosed neurodegenerative disorder affecting humans, with advanced age being the most prominent risk factor for developing AD. Despite intense research efforts aimed at elucidating the precise molecular underpinnings of AD, a definitive a...

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Detalhes bibliográficos
Main Authors: Proctor, Carole J, Pienaar, Ilse Sanet, Elson, Joanna L, Kirkwood, Thomas BL
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583291/
https://ncbi.nlm.nih.gov/pubmed/22748062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-32
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