Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach

<p>Abstract</p> <p>Background</p> <p>Alzheimer’s disease (AD) is the most frequently diagnosed neurodegenerative disorder affecting humans, with advanced age being the most prominent risk factor for developing AD. Despite intense research efforts aimed at elucidating th...

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Detalhes bibliográficos
Main Authors: Proctor Carole J, Pienaar Ilse, Elson Joanna L, Kirkwood Thomas BL
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-07-01
Colecção:Molecular Neurodegeneration
Assuntos:
Alzheimer’s disease
Amyloid-beta
Dimers
Down’s syndrome
Intervention
Immunotherapy
Mathematical model
Protein aggregation
Stochastic simulation
Acesso em linha:http://www.molecularneurodegeneration.com/content/7/1/32
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