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The aggregation kinetics of Alzheimer’s β-amyloid peptide is controlled by stochastic nucleation

We report here a recombinant expression system that allows production of large quantities of Alzheimer’s Aβ(1–40) peptide. The material is competent to dissolve in water solutions with “random-coil properties,” although its conformation and factual oligomerization state are determined by the physico...

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Detalhes bibliográficos
Main Authors: Hortschansky, Peter, Schroeckh, Volker, Christopeit, Tony, Zandomeneghi, Giorgia, Fändrich, Marcus
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2253354/
https://ncbi.nlm.nih.gov/pubmed/15937275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.041266605
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