Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy

AIMS: Duchenne muscular dystrophy (DMD) is a muscle disease with serious cardiac complications. Changes in Ca(2+) homeostasis and oxidative stress were recently associated with cardiac deterioration, but the cellular pathophysiological mechanisms remain elusive. We investigated whether the activity...

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Autors principals: Kyrychenko, Sergii, Poláková, Eva, Kang, Chifei, Pocsai, Krisztina, Ullrich, Nina D., Niggli, Ernst, Shirokova, Natalia
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Original Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583259/
https://ncbi.nlm.nih.gov/pubmed/23263329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs425
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