Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

AIMS: Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause...

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Main Authors: Langley, Sarah R., Bottolo, Leonardo, Kunes, Jaroslav, Zicha, Josef, Zidek, Vaclav, Hubner, Norbert, Cook, Stuart A., Pravenec, Michal, Aitman, Timothy J., Petretto, Enrico
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583256/
https://ncbi.nlm.nih.gov/pubmed/23118132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs329
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