Systems-level approaches reveal conservation of trans-regulated genes in the rat and genetic determinants of blood pressure in humans

AIMS: Human genome-wide association studies (GWAS) of hypertension identified only few susceptibility loci with large effect that were replicated across populations. The vast majority of genes detected by GWAS has small effect and the regulatory mechanisms through which these genetic variants cause...

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Main Authors: Langley, Sarah R., Bottolo, Leonardo, Kunes, Jaroslav, Zicha, Josef, Zidek, Vaclav, Hubner, Norbert, Cook, Stuart A., Pravenec, Michal, Aitman, Timothy J., Petretto, Enrico
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2013
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Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583256/
https://ncbi.nlm.nih.gov/pubmed/23118132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs329
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