Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. In cold-blooded vertebrates, computational CGI predictions often reside away from gene promoters, suggesting...

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Autores principales: Long, Hannah K, Sims, David, Heger, Andreas, Blackledge, Neil P, Kutter, Claudia, Wright, Megan L, Grützner, Frank, Odom, Duncan T, Patient, Roger, Ponting, Chris P, Klose, Robert J
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2013
Materias:
Genes and Chromosomes
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583005/
https://ncbi.nlm.nih.gov/pubmed/23467541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00348
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