Development of K562 cell clones expressing β-globin mRNA carrying the β(0)39 thalassaemia mutation for the screening of correctors of stop-codon mutations

Nonsense mutations, giving rise to UAA, UGA and UAG stop codons within the coding region of mRNAs, promote premature translational termination and are the leading cause of approx. 30 % of inherited diseases, including cystic fibrosis, Duchenne muscular dystrophy and thalassaemia. For instance, in β(...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Salvatori, Francesca, Cantale, Vera, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Bianchi, Nicoletta, Borgatti, Monica, Feriotto, Giordana, Destro, Federica, Canella, Alessandro, Breda, Laura, Rivella, Stefano, Gambari, Roberto
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582994/
https://ncbi.nlm.nih.gov/pubmed/19216718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BA20080266
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi