Development of K562 cell clones expressing β-globin mRNA carrying the β(0)39 thalassaemia mutation for the screening of correctors of stop-codon mutations

Nonsense mutations, giving rise to UAA, UGA and UAG stop codons within the coding region of mRNAs, promote premature translational termination and are the leading cause of approx. 30 % of inherited diseases, including cystic fibrosis, Duchenne muscular dystrophy and thalassaemia. For instance, in β(...

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Main Authors: Salvatori, Francesca, Cantale, Vera, Breveglieri, Giulia, Zuccato, Cristina, Finotti, Alessia, Bianchi, Nicoletta, Borgatti, Monica, Feriotto, Giordana, Destro, Federica, Canella, Alessandro, Breda, Laura, Rivella, Stefano, Gambari, Roberto
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582994/
https://ncbi.nlm.nih.gov/pubmed/19216718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BA20080266
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