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Cell autonomous and non-autonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair
Daily cells incur tens of thousands of DNA lesions caused by endogenous processes. Due to their long-lived nature, adult stem cells may be particularly susceptible to the negative impact of this constant genotoxic stress. Indeed, in murine models of DNA repair deficiencies, there is accumulation of...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582850/ https://ncbi.nlm.nih.gov/pubmed/23097336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1261 |
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