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DNA repair is crucial for maintaining hematopoietic stem cell function
Richard Cornall and collaborators recently developed a mouse model of Ligase IV syndrome with growth retardation and immunodeficiency due to a defect in nonhomologous end-joining (NHEJ) of DNA double-strand breaks. They demonstrated age-dependent loss of hematopoietic stem cell function in these mic...
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2731414/ https://ncbi.nlm.nih.gov/pubmed/18248857 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.11.012 |
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