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Cell autonomous and non-autonomous mechanisms drive hematopoietic stem/progenitor cell loss in the absence of DNA repair
Daily cells incur tens of thousands of DNA lesions caused by endogenous processes. Due to their long-lived nature, adult stem cells may be particularly susceptible to the negative impact of this constant genotoxic stress. Indeed, in murine models of DNA repair deficiencies, there is accumulation of...
Tallennettuna:
| Päätekijät: | , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2013
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582850/ https://ncbi.nlm.nih.gov/pubmed/23097336 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1261 |
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