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Increased expression of a short splice variant of CTLA-4 exacerbates lupus in MRL/lpr mice
BACKGROUND: CTLA-4 is a negative regulator of the immune response expressed by regulatory T cells and activated T cells. Polymorphisms in the CTLA4 gene have been associated with autoimmune diseases including systemic lupus erythematosus. Disease-associated polymorphisms have been shown to affect th...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582760/ https://ncbi.nlm.nih.gov/pubmed/23203389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.37790 |
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