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Instability of CTG Repeats is Governed by the Position of a DNA Base Lesion through Base Excision Repair

Trinucleotide repeat (TNR) expansions and deletions are associated with human neurodegeneration and cancer. However, their underlying mechanisms remain to be elucidated. Recent studies have demonstrated that CAG repeat expansions can be initiated by oxidative DNA base damage and fulfilled by base ex...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lai, Yanhao, Xu, Meng, Zhang, Zunzhen, Liu, Yuan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582642/
https://ncbi.nlm.nih.gov/pubmed/23468897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0056960
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