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The Structures of the E22Δ Mutant-Type Amyloid-β Alloforms and the Impact of E22Δ Mutation on the Structures of the Wild-Type Amyloid-β Alloforms

[Image: see text] Structural differences between the intrinsically disordered fibrillogenic wild-type Aβ40 and Aβ42 peptides are linked to Alzheimer’s disease. Recently, the E22Δ genetic missense mutation was detected in patients exhibiting Alzheimer’s-disease type dementia. However, detailed knowle...

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Bibliografiset tiedot
Päätekijät: Coskuner, Orkid, Wise-Scira, Olivia, Perry, George, Kitahara, Taizo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2012
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582298/
https://ncbi.nlm.nih.gov/pubmed/23421682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300149j
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