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Structures and Free Energy Landscapes of the Wild-Type and A30P Mutant-Type α-Synuclein Proteins with Dynamics

[Image: see text] The genetic missense A30P mutation of the wild-type α-synuclein protein results in the replacement of the 30th amino acid residue from alanine (Ala) to proline (Pro) and was initially found in the members of a German family who developed Parkinson’s disease. Even though the structu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Wise-Scira, Olivia, Aloglu, Ahmet Kemal, Dunn, Aquila, Sakallioglu, Isin Tuna, Coskuner, Orkid
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2013
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3607329/
https://ncbi.nlm.nih.gov/pubmed/23374072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn300198q
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