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Arginine and Disordered Amyloid-β Peptide Structures: Molecular Level Insights into the Toxicity in Alzheimer’s Disease

[Image: see text] Recent studies present that the single arginine (R) residue in the sequence of Aβ42 adopts abundant β-sheet structure and forms stable salt bridges with various residues. Furthermore, experiments proposed that R stimulates the Aβ assembly and arginine (R) to alanine (A) mutation (R...

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Autors principals: Coskuner, Orkid, Wise-Scira, Olivia
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2013
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3867960/
https://ncbi.nlm.nih.gov/pubmed/24041422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn4001389
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