DNA and virus particle vaccination protects against acquisition and confers control of viremia upon heterologous simian immunodeficiency virus challenge

We have previously shown that macaques vaccinated with DNA vectors expressing SIVmac239 antigens developed potent immune responses able to reduce viremia upon high-dose SIVmac251 challenge. To further improve vaccine-induced immunity and protection, we combined the SIVmac239 DNA vaccine with protein...

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Autors principals: Patel, Vainav, Jalah, Rashmi, Kulkarni, Viraj, Valentin, Antonio, Rosati, Margherita, Alicea, Candido, von Gegerfelt, Agneta, Huang, Wensheng, Guan, Yongjun, Keele, Brandon F., Bess, Julian W., Piatak, Michael, Lifson, Jeffrey D., Williams, William T., Shen, Xiaoying, Tomaras, Georgia D., Amara, Rama R., Robinson, Harriet L., Johnson, Welkin, Broderick, Kate E., Sardesai, Niranjan Y., Venzon, David J., Hirsch, Vanessa M., Felber, Barbara K., Pavlakis, George N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581900/
https://ncbi.nlm.nih.gov/pubmed/23359688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1215393110
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