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On the role of TolC in multidrug efflux: the function and assembly of AcrAB-TolC tolerate significant depletion of intracellular TolC protein
TolC channel provides a route for the expelled drugs and toxins to cross the outer membrane of Escherichia coli. The puzzling feature of TolC structure is that the periplasmic entrance of the channel is closed by dense packing of twelve α-helices. Efflux pumps exemplified by AcrAB are proposed to dr...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3581732/ https://ncbi.nlm.nih.gov/pubmed/23331412 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12143 |
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