Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression

Cancer-initiating cells comprise a heterogeneous population of undifferentiated cells with the capacity for self-renewal and high proliferative potential. We investigated the role of uPAR and cathepsin B in the maintenance of stem cell nature in glioma-initiating cells (GICs). Simultaneous knockdown...

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Main Authors: Gopinath, Sreelatha, Malla, RamaRao, Alapati, Kiranmai, Gorantla, Bharathi, Gujrati, Meena, Dinh, Dzung H., Rao, Jasti S.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581601/
https://ncbi.nlm.nih.gov/pubmed/23222817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgs375
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