Runx2 Protein Represses Axin2 Expression in Osteoblasts and Is Required for Craniosynostosis in Axin2-deficient Mice

Runx2 and Axin2 regulate craniofacial development and skeletal maintenance. Runx2 is essential for calvarial bone development, as Runx2 haploinsufficiency causes cleidocranial dysplasia. In contrast, Axin2-deficient mice develop craniosynostosis because of high β-catenin activity. Axin2 levels are e...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: McGee-Lawrence, Meghan E., Li, Xiaodong, Bledsoe, Krista L., Wu, Hai, Hawse, John R., Subramaniam, Malayannan, Razidlo, David F., Stensgard, Bridget A., Stein, Gary S., van Wijnen, Andre J., Lian, Jane B., Hsu, Wei, Westendorf, Jennifer J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3581413/
https://ncbi.nlm.nih.gov/pubmed/23300083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.414995
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados